Abstract
The separation of atropisomeric conformers of 1,2,3,4-tetrahydroisoquinoline amide Bcl-2 ligands allowed the identification of the bioactive conformer which was subsequently confirmed by X-ray crystallography.
MeSH terms
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Apoptosis
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Binding Sites
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Chemistry, Pharmaceutical / methods*
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Crystallography, X-Ray / methods
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Drug Design
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Humans
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Ligands
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Molecular Structure
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Protein Binding
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Protein Interaction Mapping
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Proto-Oncogene Proteins c-bcl-2 / chemistry*
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Structure-Activity Relationship
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Tetrahydroisoquinolines / chemistry*
Substances
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Ligands
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Proto-Oncogene Proteins c-bcl-2
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Tetrahydroisoquinolines
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1,2,3,4-tetrahydroisoquinoline